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Proteomics Analysis—Orbitrap Fusion Tribird

Proteomics research is not only essential for exploring the mysteries of life but can also be of great benefit to human health. Proteomics research is a feature of the post-genetic era in the life sciences. Creative Proteomics can accurately identify and quantify proteins in biological systems by mass spectrometry. We are well equipped to provide Orbitrap Fusion Tribird-based proteomics analysis services.

Name of the Instrument/Technicial Service

Orbitrap Fusion Tribird

Introduction

1. Uncompromising Performance 1) Ultrahigh resolution up to 500,000 FWHM removes interferences 2) Precursor selection using a quadrupole mass filter allows the ion trap and Orbitrap mass analyzers to operate in parallel for excellent sensitivity and selectivity 3) Multiple dissociation techniques-CID, HCD, and optional ETD-with ion trap or Orbitrap detection at any level of MSn maximize flexibility for research applications 4) Flexibility of fragmentation-CID-HCD, HCD-CID, and HCD-HCD-at any stage of MSn analysis with fragment ions detected by either mass analyzer enables detailed structure determination of metabolites, glycans and other small molecules 5) Active beam guide with axial field reduces noise and increases robustness 6) Novel Orbitrap analyzer design and dual-pressure ion trap configuration provide fast MS/MS scan rates up to 20 Hz with unmatched spectral quality 7) Thermo Scientific Easy-Max NG and optional Thermo Scientific Ion Max NG and Nanospray Flex NG ion sources deliver next-generation performance 2. Unrivaled Proteomics Capabilities 1) Wide dynamic range and ultrahigh mass resolution allow identification of more low-abundance proteins with confidence 2) Ultrahigh mass resolution is ideal for analysis of monoclonal antibodies and other intact proteins 3) Sub-1-ppm mass accuracy provided by the optional Thermo Scientific EASY-IC ion source with internal calibration adds confidence to protein quantification results 4) Automated Synchronous Precursor Selection (SPS) for MS3 significantly increases the number of peptides and proteins identified and improves quantitative accuracy when using isobaric mass tags 5) Simple, reliable Thermo Scientific EASY-ETD ion source (optional) complements CID and HCD data and enhances characterization of complex Ps

Summary

The Orbitrap Fusion Tribrid Mass Spectrometer enables scientists analyzing the most challenging low-abundance, high-complexity samples to identify more compounds faster, quantify more accurately and elucidate structures more thoroughly.

The dedicated Creative Proteomics team can provide our clients with proteomics analysis services based on Orbitrap Fusion Tribird. If this is of interest to you, please feel free to contact us.

For research use only, not intended for any clinical use.

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